Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Rad50tm1Jpt Name: RAD50 double strand break repair protein; targeted mutation 1, John H J Petrini MGI ID: MGI:2387852 Synonyms: m1, mrad50Brdm1, Rad50delta Gene: Rad50  Location: Chr11:53540346-53598146 bp, - strand  Genetic Position: Chr11, 31.98 cM, cytoband A5-B1 Alliance: Rad50tm1Jpt page

Development of Rad50tm1Jpt/Rad50tm1Jpt embryos Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:56083
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by replacement of exon 1 with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos were identified by PCR genotyping. (J:56083)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rad50 Mutation:	53 strains or lines available

Original:	J:56083 Luo G, et al., Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7376-81
All:	4 reference(s)