Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vav1tm2Bbd
Name:	vav 1 oncogene; targeted mutation 2, Mariano Barbacid
MGI ID:	MGI:2387840
Synonyms:	vav-
Gene:	Vav1  Location: Chr17:57586100-57635031 bp, + strand  Genetic Position: Chr17, 29.76 cM
Alliance:	Vav1tm2Bbd page

Germline Transmission:	Earliest citation of germline transmission: J:47596
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequences encoding amino acids 135-195 comprising the entire acidic domain were replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in thymocytes of homozygous mutant animals. (J:47596)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vav1 Mutation:	58 strains or lines available

Original:	J:47596 Fischer KD, et al., Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol. 1998 May 7;8(10):554-62
All:	16 reference(s)