Pafah1b1tm1Or
Targeted Allele Detail
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| Symbol: |
Pafah1b1tm1Or |
| Name: |
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; targeted mutation 1, Orly Reiner |
| MGI ID: |
MGI:2387783 |
| Synonyms: |
sLIS1 |
| Gene: |
Pafah1b1 Location: Chr11:74564775-74615210 bp, - strand Genetic Position: Chr11, 45.76 cM, cytoband B3
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| Alliance: |
Pafah1b1tm1Or page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:69631
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: Flanking loxP sites and a neo cassette were introduced to the first ATG codon via homologous recombination. The ATG and neo cassette were removed by mating mutant animals to a PGK-cre line. The deletion results in translation from the second methionine and produces a shorter protein of 345 amino acids (instead of 409 amino acids). The mutant allele was confirmed by Western blot analysis of brain extracts from heterozygous animals. No homozygous mutant animals were born.
(J:69631)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pafah1b1 Mutation: |
159 strains or lines available
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| Original: |
J:69631 Cahana A, et al., Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6429-34 |
| All: |
5 reference(s) |
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Analysis Tools
