Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plk4tm1Jwd
Name:	polo like kinase 4; targeted mutation 1, James W Dennis
MGI ID:	MGI:2387766
Synonyms:	Plk4-, Sak-
Gene:	Plk4  Location: Chr3:40754463-40771318 bp, + strand  Genetic Position: Chr3, 19.54 cM
Alliance:	Plk4tm1Jwd page

Germline Transmission:	Earliest citation of germline transmission: J:68142
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 and 2 were replaced with a neomycin resistance cassette via homologous recombination. The targeted mutation deletes the translation initiation site and part of the kinase domain. (J:68142)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plk4 Mutation:	36 strains or lines available

Original:	J:68142 Hudson JW, et al., Late mitotic failure in mice lacking Sak, a polo-like kinase. Curr Biol. 2001 Mar 20;11(6):441-6
All:	5 reference(s)