Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	St3gal1tm1Jxm
Name:	ST3 beta-galactoside alpha-2,3-sialyltransferase 1; targeted mutation 1, Jamey Marth
MGI ID:	MGI:2387752
Synonyms:	ST3Gal-Idelta
Gene:	St3gal1  Location: Chr15:66974724-67048575 bp, - strand  Genetic Position: Chr15, 29.3 cM
Alliance:	St3gal1tm1Jxm page

Germline Transmission:	Earliest citation of germline transmission: J:79167
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was flanked by loxP sites and a loxP-tk-neo cassette was inserted into the upstream intron via homologous recombination. Transient expression of cre recominase in correctly targeted cells facilitated the removal of exon 2 and the loxP-tk-neo cassette resulting in deletion of the sialyl motif essential for catalysis. (J:79167)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any St3gal1 Mutation:	41 strains or lines available

Original:	J:79167 Priatel JJ, et al., The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity. 2000 Mar;12(3):273-83
All:	9 reference(s)