Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thrsptm1Cnm
Name:	thyroid hormone responsive; targeted mutation 1, Cary N Mariash
MGI ID:	MGI:2387689
Gene:	Thrsp  Location: Chr7:97062140-97066757 bp, - strand  Genetic Position: Chr7, 53.49 cM, cytoband E3
Alliance:	Thrsptm1Cnm page

Germline Transmission:	Earliest citation of germline transmission: J:71785
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of a large portion of exon 1 with a PGK-neo cassette. The targeted mutation deletes sequences encoding amino acids 22-150. Northern blot analysis and quantitative RT-PCR was unable to detect gene transcripts from hepatic mRNA of homozygous mutant animals, thus confirming the null allele. (J:71785)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thrsp Mutation:	13 strains or lines available

Original:	J:71785 Zhu Q, et al., Spot 14 Gene Deletion Increases Hepatic de Novo Lipogenesis. Endocrinology. 2001 Oct;142(10):4363-70
All:	6 reference(s)