Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdk5r2tm1Lht
Name:	cyclin dependent kinase 5, regulatory subunit 2; targeted mutation 1, Li-Huei Tsai
MGI ID:	MGI:2387662
Synonyms:	p39-
Gene:	Cdk5r2  Location: Chr1:74894188-74896891 bp, + strand  Genetic Position: Chr1, 38.54 cM, cytoband C3
Alliance:	Cdk5r2tm1Lht page

Germline Transmission:	Earliest citation of germline transmission: J:71181
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette in the reverse orientation replaced 1 kb of the coding region resulting in deletion of amino acids 1-346 and 100 bp of upstream noncoding sequences. Absence of gene expression in homozygous animals was demonstrated by Western blot analysis of whole brain lysates. Histone 1 kinase activity is also absent in brain lysates of homozygous mutant animals. (J:71181)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

94 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk5r2 Mutation:	9 strains or lines available

Original:	J:71181 Ko J, et al., p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci. 2001 Sep 1;21(17):6758-71
All:	10 reference(s)