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Dusp9 Gene Detail
Summary
  • Symbol
    Dusp9
  • Name
    dual specificity phosphatase 9
  • Synonyms
    Mpk4, Pyst3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387107
    NCBI Gene: 75590
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72683025-72687120 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.37 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387107
 protein coding gene ChrX:72682995-72687120 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035813
 protein coding gene ChrX:69406388-69410489 (+)
A/J MGP_AJ_G0035794
 protein coding gene ChrX:69607081-69611176 (+)
AKR/J MGP_AKRJ_G0035719
 protein coding gene ChrX:71415004-71419099 (+)
BALB/cJ MGP_BALBcJ_G0035779
 protein coding gene ChrX:68640134-68644229 (+)
C3H/HeJ MGP_C3HHeJ_G0035484
 protein coding gene ChrX:69877988-69882083 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036309
 protein coding gene ChrX:71539177-71543272 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033153
 protein coding gene ChrX:68644401-68648465 (+)
CAST/EiJ MGP_CASTEiJ_G0034775
 protein coding gene ChrX:55226760-55230858 (+)
CBA/J MGP_CBAJ_G0035459
 protein coding gene ChrX:73487784-73491879 (+)
DBA/2J MGP_DBA2J_G0035616
 protein coding gene ChrX:69070515-69074610 (+)
FVB/NJ MGP_FVBNJ_G0035560
 protein coding gene ChrX:68398042-68402137 (+)
LP/J MGP_LPJ_G0035701
 protein coding gene ChrX:70192609-70196710 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035598
 protein coding gene ChrX:76075909-76080004 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036331
 protein coding gene ChrX:69231397-69235498 (+)
PWK/PhJ MGP_PWKPhJ_G0034474
 protein coding gene ChrX:53243047-53247103 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034308
 protein coding gene ChrX:56137097-56141205 (+)
WSB/EiJ MGP_WSBEiJ_G0034916
 protein coding gene ChrX:68500603-68504700 (+)



Homology
more
  • Human Ortholog
    DUSP9, dual specificity phosphatase 9
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUSP9, dual specificity phosphatase 9
  • Synonyms
    MKP4, MKP-4
  • Links
    NCBI Gene ID: 1852
    neXtProt AC: NX_Q99956
    UniProt: Q99956

  • Chr Location
    Xq28; chrX:153642441-153651326 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous null male and heterozygous null female mice display embryonic lethality during organogenesis with abnormal placental labyrinth morphology when the allele is maternally inherited. Tetraploid rescue produces viable heterozygous and hemizygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    990
  • Tissues
    183
  • cDNA Data
    47
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031383 Ensembl Gene Model | MGI Sequence Detail 4096 C57BL/6J ±  kb
    transcript ENSMUST00000019701 Ensembl | MGI Sequence Detail 2722 Not Applicable  
    polypeptide ENSMUSP00000019701 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
      3.1.3.16, 3.1.3.48
    • InterPro Domains
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR020422 Dual specificity protein phosphatase domain
      IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
      IPR029021 Protein-tyrosine phosphatase-like
      IPR001763 Rhodanese-like domain
      IPR036873 Rhodanese-like domain superfamily
      IPR000387 Tyrosine-specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 1
      cDNA 47
      Primer pair 3
      Other 1

      Microarray probesets 12
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 12
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:76596 Dickinson RJ, et al., Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase. Biochem J. 2002 May 15;364(Pt 1):145-55
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory