Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Oprd1tm1Kff
Name:	opioid receptor, delta 1; targeted mutation 1, Brigitte L Kieffer
MGI ID:	MGI:2387013
Synonyms:	DOR-, Oprd1-
Gene:	Oprd1  Location: Chr4:131838037-131871797 bp, - strand  Genetic Position: Chr4, 64.78 cM, cytoband D1-D3
Alliance:	Oprd1tm1Kff page

Germline Transmission:	Earliest citation of germline transmission: J:62551
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1, which encodes the translational start codon, was replaced by a neomycin selection cassette inserted by homologous recombination. A radiolabeled binding assay demonstrated complete functional ablation in homozygous mutant mice. (J:62551)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oprd1 Mutation:	29 strains or lines available

Original:	J:62551 Filliol D, et al., Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet. 2000 Jun;25(2):195-200
All:	27 reference(s)