Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ngfrtm1Gdc
Name:	nerve growth factor receptor (TNFR superfamily, member 16); targeted mutation 1, Georg Dechant
MGI ID:	MGI:2386981
Synonyms:	p75e4-, p75exonIV-, p75(IV)-, p75NTRexonIV
Gene:	Ngfr  Location: Chr11:95459644-95478524 bp, - strand  Genetic Position: Chr11, 59.01 cM
Alliance:	Ngfrtm1Gdc page

Germline Transmission:	Earliest citation of germline transmission: J:71955
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGK-neo cassette was inserted into exon 4 of the endogenous locus by homologous recombination. Western blot analysis confirmed the absence of both known isoforms, to which exon 4 is common. (J:71955)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ngfr Mutation:	30 strains or lines available

Original:	J:71955 von Schack D, et al., Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat Neurosci. 2001 Oct;4(10):977-8
All:	19 reference(s)