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Adcyap1tm1Nms
Targeted Allele Detail
Summary
Symbol: Adcyap1tm1Nms
Name: adenylate cyclase activating polypeptide 1; targeted mutation 1, Nancy M Sherwood
MGI ID: MGI:2386973
Synonyms: PACAP-
Gene: Adcyap1  Location: Chr17:93506448-93513967 bp, + strand  Genetic Position: Chr17, 60.67 cM
Alliance: Adcyap1tm1Nms page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71968
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe in vitro expression of cre recombinase resulted in the excision of a floxed fragment containing all of exons 3 and 4 and a portion of exon 5. Protein was undetected in homozygous mutant mice by Western blot analysis of brain tissue. (J:71968)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1 Mutation:  22 strains or lines available
References
Original:  J:71968 Gray SL, et al., Targeted disruption of the pituitary adenylate cyclase-activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism. Mol Endocrinol. 2001 Oct;15(10):1739-47
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory