About   Help   FAQ
Rgs9tm1Citb
Targeted Allele Detail
Summary
Symbol: Rgs9tm1Citb
Name: regulator of G-protein signaling 9; targeted mutation 1, California Institute of Technology - Biology
MGI ID: MGI:2386798
Synonyms: RGS9-, RGS9-2 KO
Gene: Rgs9  Location: Chr11:109116181-109188955 bp, - strand  Genetic Position: Chr11, 71.86 cM
Alliance: Rgs9tm1Citb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60188
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 5.5 kb region containing exons 2-4 (encoding amino acids 19-105) was replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutant animals lacked protein product as determined by Western blot analysis of retinal proteins. Mutant retinas failed to express the long form of G protein, beta 5 (GNB5-L), although normal amounts of its mRNA were still present; however, a normal protein level of the short form GNB5-S was detected in the retina and striatum of mutant mice. (J:60188, J:83620)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rgs9 Mutation:  34 strains or lines available
References
Original:  J:60188 Chen CK, et al., Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature. 2000 Feb 3;403(6769):557-60
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory