Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stat6tm1Jni
Name:	signal transducer and activator of transcription 6; targeted mutation 1, James N Ihle
MGI ID:	MGI:2386745
Synonyms:	Stat6-
Gene:	Stat6  Location: Chr10:127478855-127496826 bp, + strand  Genetic Position: Chr10, 74.59 cM
Alliance:	Stat6tm1Jni page

Germline Transmission:	Earliest citation of germline transmission: J:32607
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The first coding exon was replaced with a neomycin resistance gene via homologous recombination. Immunoprecipitation and Western blot analysis using an antibody directed against the C-terminus of the protein did not detect wild-type gene product in homozygous mutant animals. However, a smaller protein was detected at low levels, possibly produced from residual transcripts. Il4-induced DNA-binding activity of Stat6 was not present in homozygous mutant animals. (J:32607)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat6 Mutation:	51 strains or lines available

Original:	J:32607 Shimoda K, et al., Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996 Apr 18;380(6575):630-3
All:	37 reference(s)