Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc6a3tm1Mca
Name:	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Marc G Caron
MGI ID:	MGI:2386303
Synonyms:	DAT-, DAT-KO
Gene:	Slc6a3  Location: Chr13:73684866-73726791 bp, + strand  Genetic Position: Chr13, 40.1 cM
Alliance:	Slc6a3tm1Mca page

Germline Transmission:	Earliest citation of germline transmission: J:31328
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into a coding exon via homologous recombination. Gene expression is absent in the ventral tegmental area (VTA) and dopaminergic cells of the substantia nigra pars compacta (SNC) in homozygous animals as shown by in situ hybridization analysis. (J:31328)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:	66 strains or lines available

Original:	J:31328 Giros B, et al., Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 1996 Feb 15;379(6566):606-12
All:	94 reference(s)