Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adcyap1r1tm1Aba
Name:	adenylate cyclase activating polypeptide 1 receptor 1; targeted mutation 1, Akemichi Baba
MGI ID:	MGI:2386283
Synonyms:	exon 2-
Gene:	Adcyap1r1  Location: Chr6:55428963-55478436 bp, + strand  Genetic Position: Chr6, 27.38 cM, cytoband B3
Alliance:	Adcyap1r1tm1Aba page

Germline Transmission:	Earliest citation of germline transmission: J:65199
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The insertion of a neomycin selection cassette disrupted exon 2, which encodes the 5' untranslated region, the start codon, and the majority of the signal peptide. Northern blot and RT-PCR analyses identified an aberrant transcript in which exon 1 had spliced to exon 3. In vitro studies of the protein generated from a start codon in exon 3 of this transcript showed improper localization and post-translational processing. Specifically, cell surface expression of the mutant protein was reduced and it was largely unglycosylated. (J:65199)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1r1 Mutation:	34 strains or lines available

Original:	J:65199 Hashimoto H, et al., Mice with markedly reduced PACAP (PAC(1)) receptor expression by targeted deletion of the signal peptide. J Neurochem. 2000 Nov;75(5):1810-7
All:	3 reference(s)