Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tyrobptm1Lll
Name:	TYRO protein tyrosine kinase binding protein; targeted mutation 1, Lewis L Lanier
MGI ID:	MGI:2386277
Synonyms:	DAP12-
Gene:	Tyrobp  Location: Chr7:30113207-30117007 bp, + strand  Genetic Position: Chr7, 17.45 cM, cytoband B
Alliance:	Tyrobptm1Lll page

Germline Transmission:	Earliest citation of germline transmission: J:64763
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 and 4 were deleted by the insertion of a floxed neo cassette, which was subsequently excised via the in vitro expression of cre recombinase. The targeted region encoded the transmembrane domain and a portion of the cytoplasmic domain including the first tyrosine of the immunoreceptor tyrosine-based activation motif (ITAM). The ablation of protein expression in homozygous mutant mice was confirmed via immunohistochemical analysis of spleen sections. (J:64763)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyrobp Mutation:	10 strains or lines available

Original:	J:64763 Bakker AB, et al., DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. Immunity. 2000 Sep;13(3):345-53
All:	49 reference(s)