Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Mmp2tm1Ito Name: matrix metallopeptidase 2; targeted mutation 1, Shigeyoshi Itohara MGI ID: MGI:2386252 Synonyms: MMP-2 -, MMP2-, MMP-2 KO Gene: Mmp2  Location: Chr8:93553920-93580049 bp, + strand  Genetic Position: Chr8, 44.99 cM Alliance: Mmp2tm1Ito page

Cardiac neutrophil accumulation post-myocardial infraction is normalized in Timp4tm1Vuo/Timp4tm1Vuo Mmp2tm1Ito/Mmp2tm1Ito mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:42742
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 5.9 kb of the gene including exon 1 was replaced with a PGK-neo cassette via homologous recombination. Absence of protein activity in the brain, lungs, and kidneys of homozygous mutant animals was confirmed by gelatin zymography. (J:42742)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

List all tumor models in MMHCdb carrying Mmp2tm1Ito

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mmp2 Mutation:	25 strains or lines available

Original:	J:42742 Itoh T, et al., Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J Biol Chem. 1997 Sep 5;272(36):22389-92
All:	134 reference(s)