About   Help   FAQ
Mmp14tm1Ktry
Targeted Allele Detail
Summary
Symbol: Mmp14tm1Ktry
Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Karl Tryggvason
MGI ID: MGI:2386246
Synonyms: Mmp13tm1Ktry
Gene: Mmp14  Location: Chr14:54669055-54679913 bp, + strand  Genetic Position: Chr14, 27.79 cM
Alliance: Mmp14tm1Ktry page
Histology and immunohistology of growth zones in distal femur of Mmp14tm1Ktry/Mmp14tm1Ktry mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61685
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details0.5 kb of the gene including part of exon 4 was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of lung and heart from homozygous mutant mice confirmed the absence of gene expression. (J:61685)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 22 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp14 Mutation:  43 strains or lines available
References
Original:  J:61685 Zhou Z, et al., Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory