Mmp14tm1Ktry
Targeted Allele Detail
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Symbol: |
Mmp14tm1Ktry |
Name: |
matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Karl Tryggvason |
MGI ID: |
MGI:2386246 |
Synonyms: |
Mmp13tm1Ktry |
Gene: |
Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
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Alliance: |
Mmp14tm1Ktry page
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Histology and immunohistology of growth zones in distal femur of Mmp14tm1Ktry/Mmp14tm1Ktry mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:61685
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: 0.5 kb of the gene including part of exon 4 was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of lung and heart from homozygous mutant mice confirmed the absence of gene expression.
(J:61685)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mmp14 Mutation: |
43 strains or lines available
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Original: |
J:61685 Zhou Z, et al., Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7 |
All: |
21 reference(s) |
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