Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ogg1tm1Tno
Name:	8-oxoguanine DNA-glycosylase 1; targeted mutation 1, Tetsuo Noda
MGI ID:	MGI:2386212
Synonyms:	Mmh-, Ogg1-
Gene:	Ogg1  Location: Chr6:113303959-113311149 bp, + strand  Genetic Position: Chr6, 52.75 cM, cytoband E-F1
Alliance:	Ogg1tm1Tno page

Germline Transmission:	Earliest citation of germline transmission: J:61684
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Half of exon 2 and the entire exon 3 were replaced with a PGK-neo cassette via homologous recombination. Gene expression and enzyme activity is absent in liver extracts from homozygous mutant animals as shown by Northern blot analysis and enzyme assay. (J:61684)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Ogg1tm1Tno

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ogg1 Mutation:	23 strains or lines available

Original:	J:61684 Minowa O, et al., Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61
All:	7 reference(s)