Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lyntm1Tya
Name:	LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Tadashi Yamamoto
MGI ID:	MGI:2386196
Synonyms:	lyn-
Gene:	Lyn  Location: Chr4:3676865-3791612 bp, + strand  Genetic Position: Chr4, 2.05 cM
Alliance:	Lyntm1Tya page

Germline Transmission:	Earliest citation of germline transmission: J:29751
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 4, which encodes the amino terminal portion of the SH3 domain, was disrupted by the insertion of neomycin selection cassette. The absence of both isoforms was verified by Western blot analysis of spleen and cerebellum tissue obtained from homozygous mutant mice. (J:29751)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lyn Mutation:	64 strains or lines available

Original:	J:29751 Nishizumi H, et al., Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity. 1995 Nov;3(5):549-60
All:	23 reference(s)