Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Zfpm2tm1Sho Name: zinc finger protein, multitype 2; targeted mutation 1, Stuart Orkin MGI ID: MGI:2386183 Synonyms: Fog2-, FOG-2- Gene: Zfpm2  Location: Chr15:40518438-40967988 bp, + strand  Genetic Position: Chr15, 15.74 cM, cytoband C Alliance: Zfpm2tm1Sho page

Abnormal lung development in the Zfpm2tm1Sho/Zfpm2tm1Sho mouse Show the 8 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:62879
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of sequences encoding all of the zinc finger motifs with a floxed neomycin-cytidine deaminase cassette. The floxed cassette was removed by crossing mutant animals to a cre deleter strain. Homozygous mutant embryos were detected by Southern blot analysis up to day E15.5. RNase protection assay showed an absence of Zfpm2 mRNA in hearts of E12.5 homozygous mutant embryos. (J:62879)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	62 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zfpm2 Mutation:	47 strains or lines available

Original:	J:62879 Tevosian SG, et al., FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000 Jun 23;101(7):729-39
All:	15 reference(s)