Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	P2rx7tm1Gab
Name:	purinergic receptor P2X, ligand-gated ion channel, 7; targeted mutation 1, Christopher A Gabel
MGI ID:	MGI:2386080
Synonyms:	P2X7-, P2X7 KO, P2X7R-, P2X7RDelta506-532, Pfizer P2X7-
Gene:	P2rx7  Location: Chr5:122781974-122829495 bp, + strand  Genetic Position: Chr5, 62.5 cM, cytoband F
Alliance:	P2rx7tm1Gab page

Germline Transmission:	Earliest citation of germline transmission: J:66835
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encoding amino acids 506 through 532 was replaced by the insertion of a neomycin selection cassette. Transcript was undetected by Northern blot analysis of bone marrow mast cells isolated from homozygous mutant mice. Western blot analysis of homozygous mutant peritoneal macrophages showed an absence of normal and truncated protein. Subsequent analysis found low levels of expression of the 13b isoform in the brain, salivary gland and spleen as well as a C-terminal truncated variant transcript. (J:66835, J:194518)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any P2rx7 Mutation:	52 strains or lines available

Original:	J:66835 Solle M, et al., Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem. 2001 Jan 5;276(1):125-32
All:	246 reference(s)