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Mfrp Gene Detail
Summary
  • Symbol
    Mfrp
  • Name
    membrane frizzled-related protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385957
    NCBI Gene: 259172
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44013067-44020484 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.60 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385957
 protein coding gene Chr9:44013026-44020484 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034691
 protein coding gene Chr9:42555661-42563122 (+)
A/J MGP_AJ_G0034671
 protein coding gene Chr9:41387361-41394819 (+)
AKR/J MGP_AKRJ_G0034597
 protein coding gene Chr9:42244544-42252005 (+)
BALB/cJ MGP_BALBcJ_G0034662
 protein coding gene Chr9:41127379-41134825 (+)
C3H/HeJ MGP_C3HHeJ_G0034373
 protein coding gene Chr9:42696820-42705714 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035184
 protein coding gene Chr9:43834037-43841522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032098
 protein coding gene Chr9:40978067-40985515 (+)
CAST/EiJ MGP_CASTEiJ_G0033696
 protein coding gene Chr9:42540073-42547522 (+)
CBA/J MGP_CBAJ_G0034346
 protein coding gene Chr9:45412062-45419512 (+)
DBA/2J MGP_DBA2J_G0034505
 protein coding gene Chr9:41300423-41307888 (+)
FVB/NJ MGP_FVBNJ_G0034445
 protein coding gene Chr9:40549572-40557033 (+)
LP/J MGP_LPJ_G0034586
 protein coding gene Chr9:42858739-42866200 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034489
 protein coding gene Chr9:47290017-47297487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035204
 protein coding gene Chr9:42139172-42146614 (+)
PWK/PhJ MGP_PWKPhJ_G0033401
 protein coding gene Chr9:41166595-41174034 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033236
 protein coding gene Chr9:42439486-42446961 (+)
WSB/EiJ MGP_WSBEiJ_G0033809
 protein coding gene Chr9:42176773-42184268 (+)



Homology
more
  • Human Ortholog
    MFRP, membrane frizzled-related protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFRP, membrane frizzled-related protein
  • Synonyms
    CTRP5, MCOP5, NNO2, RD6
  • Links
    NCBI Gene ID: 83552
    neXtProt AC: NX_Q9BY79
    UniProt: Q9BY79

  • Chr Location
    11q23.3; chr11:119338942-119346705 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mfrp mouse models; 4 with human MFRP associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations produce mice having small, white retinal spots and progressive photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    2
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 259172 NCBI Gene Model | MGI Sequence Detail 7418 C57BL/6J ±  kb
    transcript NM_147126 RefSeq | MGI Sequence Detail 4292 ZRU/MplStud  
    polypeptide Q8K480 UniProt | EBI | MGI Sequence Detail 584 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1
    Other
    Accession IDs
    less
    MGI:1888693
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:64087 Hawes NL, et al., Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3149-57
    • Latest
      J:333982 Kumari A, et al., Single cell RNA sequencing confirms retinal microglia activation associated with early onset retinal degeneration. Sci Rep. 2022 Sep 10;12(1):15273
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory