Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vamp3tm1Jpes
Name:	vesicle-associated membrane protein 3; targeted mutation 1, Jeffrey E Pessin
MGI ID:	MGI:2385941
Synonyms:	cebko, cellubrevin/VAMP3-, Vamp3tm1Jepn
Gene:	Vamp3  Location: Chr4:151131762-151142410 bp, - strand  Genetic Position: Chr4, 81.53 cM, cytoband E1
Alliance:	Vamp3tm1Jpes page

Germline Transmission:	Earliest citation of germline transmission: J:67364
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 7.8 kb of sequence were replaced with a neomycin selection cassette. The deleted region included exon 2, which contains the guanosine of the translational start codon, and exon 3, whcih encodes the entire coiled-coil domain. Western blot analysis of homozygous mutant mice showed an absence of the normal protein product. (J:67364)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

24 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vamp3 Mutation:	17 strains or lines available

Original:	J:67364 Yang C, et al., VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking. Mol Cell Biol. 2001 Mar;21(5):1573-80
All:	20 reference(s)