Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Nfe2l2tm1Ywk Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Yuet Wai Kan MGI ID: MGI:2385926 Synonyms: Nrf2-, NRF2-, Nrf2 KO Gene: Nfe2l2  Location: Chr2:75505857-75534985 bp, - strand  Genetic Position: Chr2, 44.75 cM Alliance: Nfe2l2tm1Ywk page

Abnormal development of Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos with increased apoptosis Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:37053
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 4.2 kb segment, includind part of exon 4 and all of exon 5, was replaced by an in-frame lacZ gene followed by a neomycin selection cassette. Northern blot analysis on RNA derived from various tissues confirmed that a fusion transcript was detectable in intestine of homozygous mice, but no wild-type transcript was detectable in any tissue. However, no fusion protein was detected by histochemical staining in any adult tissue. (J:37053)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

List all tumor models in MMHCdb carrying Nfe2l2tm1Ywk

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nfe2l2 Mutation:	88 strains or lines available

Original:	J:37053 Chan K, et al., NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13943-8
All:	212 reference(s)