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Cpne5 Gene Detail
Summary
  • Symbol
    Cpne5
  • Name
    copine V
  • Synonyms
    A830083G22Rik, MGC:47475
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385908
    NCBI Gene: 240058
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29375495-29456764 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    456 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385908
protein coding gene Chr17:29374530-29457141 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023459
protein coding gene Chr17:28662780-28752235 (-)
A/J MGP_AJ_G0023417
protein coding gene Chr17:27667502-27748041 (-)
AKR/J MGP_AKRJ_G0023382
protein coding gene Chr17:27907776-27996368 (-)
BALB/cJ MGP_BALBcJ_G0023422
protein coding gene Chr17:27951195-28032055 (-)
C3H/HeJ MGP_C3HHeJ_G0023183
protein coding gene Chr17:28297886-28381975 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023864
protein coding gene Chr17:29806427-29897720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021339
protein coding gene Chr17:25012384-25094110 (-)
CAST/EiJ MGP_CASTEiJ_G0022684
protein coding gene Chr17:28261986-28360567 (-)
CBA/J MGP_CBAJ_G0023158
protein coding gene Chr17:30917408-31005226 (-)
DBA/2J MGP_DBA2J_G0023288
protein coding gene Chr17:27214953-27295274 (-)
FVB/NJ MGP_FVBNJ_G0023258
protein coding gene Chr17:27039264-27127801 (-)
LP/J MGP_LPJ_G0023366
protein coding gene Chr17:28918466-29004112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023276
protein coding gene Chr17:30263195-30352128 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023906
protein coding gene Chr17:28367206-28456046 (-)
PWK/PhJ MGP_PWKPhJ_G0022434
protein coding gene Chr17:26033852-26132764 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022252
protein coding gene Chr17:26355080-26438670 (-)
WSB/EiJ MGP_WSBEiJ_G0022746
protein coding gene Chr17:28329830-28413364 (-)



Homology
more
  • Human Ortholog
    CPNE5, copine 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPNE5, copine 5
  • Synonyms
    COPN5, CPN5
  • Links
    NCBI Gene ID: 57699
    neXtProt AC: NX_Q9HCH3
    UniProt: Q9HCH3

  • Chr Location
    6p21.2; chr6:36740775-36839998 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal growth, brain structure, locomotor activity and memory, but show a decreased anxiety-related response in the elevated plus maze and elevated platform task.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 240058 NCBI Gene Model | MGI Sequence Detail 81270 C57BL/6J ±  kb
    transcript NM_001360239 RefSeq | MGI Sequence Detail 4417 C57BL/6  
    polypeptide Q8JZW4 UniProt | EBI | MGI Sequence Detail 593 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444312
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:86882 Creutz CE, et al., The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. J Biol Chem. 1998 Jan 16;273(3):1393-402
    • Latest
      J:335233 Astrof S, et al., Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. Dev Biol. 2023 Apr 14;499:10-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory