Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il18tm1Khe
Name:	interleukin 18; targeted mutation 1, Klaus Heeg
MGI ID:	MGI:2385814
Synonyms:	IL-18KO
Gene:	Il18  Location: Chr9:50466127-50493140 bp, + strand  Genetic Position: Chr9, 27.75 cM
Alliance:	Il18tm1Khe page

Germline Transmission:	Earliest citation of germline transmission: J:62263
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exons 5 and 7 and all of exon 6 were replaced with a neomycin resistance cassette via homologous recombination. Gene expression was absent in livers of homozygous mutant animals as demonstrated by RNase protection assay. (J:62263)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il18 Mutation:	29 strains or lines available

Original:	J:62263 Hochholzer P, et al., Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect Immun. 2000 Jun;68(6):3502-8
All:	9 reference(s)