Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tpm1tm1Jse
Name:	tropomyosin 1, alpha; targeted mutation 1, Jonathan G Seidman
MGI ID:	MGI:2385810
Gene:	Tpm1  Location: Chr9:66929872-66956688 bp, - strand  Genetic Position: Chr9, 36.27 cM
Alliance:	Tpm1tm1Jse page

Germline Transmission:	Earliest citation of germline transmission: J:44952
Parent Cell Line:	C1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The neo gene was inserted in the opposite orientation via homologous recombination at a splice junction between intron 8 and exon 9a, which also deletes 32 bp of endogenous DNA. Northern blot of E8.5 embryos using probes to exon 9a and exon 9d did not detect gene transcripts in homozygous mutants. (J:44952)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpm1 Mutation:	31 strains or lines available

Original:	J:44952 Blanchard EM, et al., Targeted ablation of the murine alpha-tropomyosin gene. Circ Res. 1997 Dec;81(6):1005-10
All:	1 reference(s)