Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ltb4r1tm1Adl
Name:	leukotriene B4 receptor 1; targeted mutation 1, Andrew D Luster
MGI ID:	MGI:2385786
Synonyms:	BLT1-, BLTR-
Gene:	Ltb4r1  Location: Chr14:56003419-56005951 bp, + strand  Genetic Position: Chr14, 28.19 cM
Alliance:	Ltb4r1tm1Adl page

Germline Transmission:	Earliest citation of germline transmission: J:63873
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 just 3' of the translation initiation codon via homologous recombination. Northern blot analysis detected a mutant transcript containing the neomycin insert in neutrophils, macrophages, lymph nodes, lung, and spleen from homozygous mutant animals. (J:63873)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltb4r1 Mutation:	20 strains or lines available

Original:	J:63873 Tager AM, et al., BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis [see comments]. J Exp Med. 2000 Aug 7;192(3):439-46
All:	48 reference(s)