Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptpretm1Ael
Name:	protein tyrosine phosphatase receptor type E; targeted mutation 1, Ari Elson
MGI ID:	MGI:2385777
Synonyms:	PTPepsilon-, Ptpre-
Gene:	Ptpre  Location: Chr7:135139210-135288022 bp, + strand  Genetic Position: Chr7, 81.27 cM
Alliance:	Ptpretm1Ael page

Germline Transmission:	Earliest citation of germline transmission: J:63866
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 13-15 which encode amino acids 262-411 and contain the catalytic residue C277 were replaced with a neomycin resistance gene via homologous recombination. This region of the genome was targeted to delete both transmembrane and cytoplasmic forms of the protein. Absence of protein expression in homozygous mutant animals was verified by Western blot analysis of brain, lung, testes, spleen, and Schwann cells. (J:63866)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpre Mutation:	40 strains or lines available

Original:	J:63866 Peretz A, et al., Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J. 2000 Aug 1;19(15):4036-45
All:	10 reference(s)