Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxa2tm2Fmr
Name:	homeobox A2; targeted mutation 2, Filippo M Rijli
MGI ID:	MGI:2385711
Synonyms:	Hoxa2EGFP(lox-neo-lox)
Gene:	Hoxa2  Location: Chr6:52139397-52141811 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance:	Hoxa2tm2Fmr page

Germline Transmission:	Earliest citation of germline transmission: J:75129
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 1, encoding the first 72 amino acids, was replaced via the insertion of the enhanced green fluorescent protein (EGFP) and a floxed neo cassette. Expression of EGFP was undetected, putatively due to the presence of the neo cassette. The deleted region corresponded to that in the conventionally targeted Hoxa2tm1Ipc. (J:75129)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa2 Mutation:	21 strains or lines available

Original:	J:75129 Pasqualetti M, et al., A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombination. Genesis. 2002 Feb;32(2):109-11
All:	8 reference(s)