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Tcaf2 Gene Detail
Summary
  • Symbol
    Tcaf2
  • Name
    TRPM8 channel-associated factor 2
  • Synonyms
    Fam115c, MGC:7793
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385258
    NCBI Gene: 232748
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:42599950-42622134 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 20.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385258
 protein coding gene Chr6:42599950-42622188 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030658
 protein coding gene Chr6:41146529-41168601 (-)
A/J MGP_AJ_G0030631
 protein coding gene Chr6:39348139-39369340 (-)
AKR/J MGP_AKRJ_G0030556
 protein coding gene Chr6:40611492-40633143 (-)
BALB/cJ MGP_BALBcJ_G0030641
 protein coding gene Chr6:39608016-39630393 (-)
C3H/HeJ MGP_C3HHeJ_G0030354
 protein coding gene Chr6:40654330-40678088 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031095
 protein coding gene Chr6:42175391-42197230 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028302
 protein coding gene Chr6:37227275-37250732 (-)
CAST/EiJ MGP_CASTEiJ_G0029758
 protein coding gene Chr6:40503551-40528610 (-)
CBA/J MGP_CBAJ_G0030329
 protein coding gene Chr6:43885746-43906958 (-)
DBA/2J MGP_DBA2J_G0030474
 protein coding gene Chr6:39199362-39220985 (-)
FVB/NJ MGP_FVBNJ_G0030430
 protein coding gene Chr6:38947601-38969130 (-)
LP/J MGP_LPJ_G0030562
 protein coding gene Chr6:41127312-41149872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030464
 protein coding gene Chr6:46148962-46177352 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031125
 protein coding gene Chr6:40589707-40610676 (-)
PWK/PhJ MGP_PWKPhJ_G0029470
 protein coding gene Chr6:38762932-38786743 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029306
 protein coding gene Chr6:40144671-40166412 (-)
WSB/EiJ MGP_WSBEiJ_G0029834
 protein coding gene Chr6:40585798-40616774 (-)



Homology
more
  • Human Ortholog
    TCAF2, TRPM8 channel associated factor 2
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCAF2, TRPM8 channel associated factor 2
  • Synonyms
    FAM115C, FAM139A, GATD9, GATD9B
  • Links
    NCBI Gene ID: 285966
    neXtProt AC: NX_A6NFQ2
    UniProt: A6NFQ2

  • Chr Location
    7q35; chr7:143620952-143730410 (+)  GRCh38
  • Human Ortholog
    TCAF2C, TRPM8 channel associated factor 2C
  • Links
    NCBI Gene ID: 100533814

  • Chr Location
    chr7:143639230-143647647 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    860
  • Tissues
    49
  • cDNA Data
    28
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232748 NCBI Gene Model | MGI Sequence Detail 22185 C57BL/6J ±  kb
    transcript NM_146174 RefSeq | MGI Sequence Detail 4257 FVB/N  
    polypeptide Q921K8 UniProt | EBI | MGI Sequence Detail 919 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR029062 Class I glutamine amidotransferase-like
      IPR035423 M60-like domain, N-terminal
      IPR031161 Peptidase family M60 domain
      IPR042279 Peptidase M60, enhancin-like domain 3
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 3
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:223963 Gkika D, et al., TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. J Cell Biol. 2015 Jan 5;208(1):89-107
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory