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Aimp2 Gene Detail
Summary
  • Symbol
    Aimp2
  • Name
    aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
  • Synonyms
    Aimp2(p38), Jtv1, MGC:30261, MGC:36346, MGC:36522, MGC:37389
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385237
    NCBI Gene: 231872
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143839522-143846657 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385237
 protein coding gene Chr5:143839522-143846665 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030339
 protein coding gene Chr5:149204974-149212115 (-)
A/J MGP_AJ_G0030308
 protein coding gene Chr5:142801151-142808392 (-)
AKR/J MGP_AKRJ_G0030240
 protein coding gene Chr5:147250820-147257961 (-)
BALB/cJ MGP_BALBcJ_G0030325
 protein coding gene Chr5:144037675-144045286 (-)
C3H/HeJ MGP_C3HHeJ_G0030036
 protein coding gene Chr5:148095437-148102644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030770
 protein coding gene Chr5:154667489-154674632 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027988
 protein coding gene Chr5:136555441-136563142 (-)
CAST/EiJ MGP_CASTEiJ_G0029441
 protein coding gene Chr5:147600867-147608015 (-)
CBA/J MGP_CBAJ_G0030006
 protein coding gene Chr5:161025107-161032252 (-)
DBA/2J MGP_DBA2J_G0030156
 protein coding gene Chr5:142558678-142565945 (-)
FVB/NJ MGP_FVBNJ_G0030111
 protein coding gene Chr5:141764155-141771447 (-)
LP/J MGP_LPJ_G0030242
 protein coding gene Chr5:149806712-149813853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030142
 protein coding gene Chr5:163402272-163410352 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030810
 protein coding gene Chr5:147138719-147145960 (-)
PWK/PhJ MGP_PWKPhJ_G0029156
 protein coding gene Chr5:141659136-141666901 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028992
 protein coding gene Chr5:144876915-144884069 (-)
WSB/EiJ MGP_WSBEiJ_G0029514
 protein coding gene Chr5:147941556-147949791 (-)



Homology
more
  • Human Ortholog
    AIMP2, aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AIMP2, aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  • Synonyms
    HLD17, JTV1, JTV-1, P38
  • Links
    NCBI Gene ID: 7965
    neXtProt AC: NX_Q13155
    UniProt: Q13155

  • Chr Location
    7p22.1; chr7:6009255-6023834 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AIMP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele are born with no apparent phenotype but die within 2 days of birth of unknown causes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    13
  • cDNA Data
    84
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 231872 NCBI Gene Model | MGI Sequence Detail 7136 C57BL/6J ±  kb
transcript NM_001172146 RefSeq | MGI Sequence Detail 1210 C57BL/6  
polypeptide Q8R010 UniProt | EBI | MGI Sequence Detail 320 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009230 aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    (term hierarchy)
  • InterPro Domains
    IPR031889 AIMP2, lysyl-tRNA synthetase binding domain
    IPR041503 AIMP2, thioredoxin-like domain
    IPR042360 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    IPR004046 Glutathione S-transferase, C-terminal
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
Molecular
Reagents
less
  • All nucleic 85
    cDNA 85

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140721, MGI:2140723
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:234840 Yum MK, et al., AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/beta-Catenin Signaling. Cancer Res. 2016 Aug 1;76(15):4559-68
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory