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Zng1 Gene Detail
Summary
  • Symbol
    Zng1
  • Name
    Zn regulated GTPase metalloprotein activator 1
  • Synonyms
    Cbwd1, MGC:28027, MGC:59411, Zng1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385089
    NCBI Gene: 226043
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:24897280-24938974 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 19.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    512 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385089
 protein coding gene Chr19:24897280-24939024 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024999
 protein coding gene Chr19:23179233-23224864 (-)
A/J MGP_AJ_G0024976
 protein coding gene Chr19:21893683-21936698 (-)
AKR/J MGP_AKRJ_G0024944
 protein coding gene Chr19:22718223-22761264 (-)
BALB/cJ MGP_BALBcJ_G0024975
 protein coding gene Chr19:21953001-21995571 (-)
C3H/HeJ MGP_C3HHeJ_G0024731
 protein coding gene Chr19:22696299-22746710 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025416
 protein coding gene Chr19:23888256-23932988 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022835
 protein coding gene Chr19:22057997-22099580 (-)
CAST/EiJ MGP_CASTEiJ_G0024201
 protein coding gene Chr19:22444253-22494394 (-)
CBA/J MGP_CBAJ_G0024709
 protein coding gene Chr19:24871555-24930654 (-)
DBA/2J MGP_DBA2J_G0024841
 protein coding gene Chr19:21900979-21944858 (-)
FVB/NJ MGP_FVBNJ_G0024803
 protein coding gene Chr19:21800439-21843998 (-)
LP/J MGP_LPJ_G0024926
 protein coding gene Chr19:23121040-23163711 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024830
 protein coding gene Chr19:24951491-25004527 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025471
 protein coding gene Chr19:22741715-22793850 (-)
PWK/PhJ MGP_PWKPhJ_G0023949
 protein coding gene Chr19:21518926-21562509 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023754
 protein coding gene Chr19:21992413-22038633 (-)
WSB/EiJ MGP_WSBEiJ_G0024268
 protein coding gene Chr19:22767120-22811490 (-)



Homology
more
  • Human Ortholog
    ZNG1A, Zn regulated GTPase metalloprotein activator 1A
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNG1A, Zn regulated GTPase metalloprotein activator 1A
  • Synonyms
    CBWD1, COBP
  • Links
    NCBI Gene ID: 55871
    neXtProt AC: NX_Q9BRT8
    UniProt: Q9BRT8

  • Chr Location
    9p24.3; chr9:120837-179147 (-)  GRCh38
  • Human Ortholog
    ZNG1B, Zn regulated GTPase metalloprotein activator 1B
  • Synonyms
    CBWD2
  • Links
    NCBI Gene ID: 150472
    neXtProt AC: NX_Q8IUF1
    UniProt: Q8IUF1

  • Chr Location
    2q14.1; chr2:113437691-113496204 (+)  GRCh38
  • Human Ortholog
    ZNG1C, Zn regulated GTPase metalloprotein activator 1C
  • Synonyms
    bA561O23.1, CBWD3
  • Links
    NCBI Gene ID: 445571
    neXtProt AC: NX_Q5JTY5
    UniProt: Q5JTY5

  • Chr Location
    9q21.11; chr9:68232003-68300035 (+)  GRCh38
  • Human Ortholog
    ZNG1E, Zn regulated GTPase metalloprotein activator 1E
  • Synonyms
    CBWD3, CBWD5, DC36
  • Links
    NCBI Gene ID: 220869
    neXtProt AC: NX_Q5JTY5, NX_Q5RIA9
    UniProt: Q5RIA9

  • Chr Location
    9q21.11; chr9:65652979-65734041 (+)  GRCh38
  • Human Ortholog
    ZNG1F, Zn regulated GTPase metalloprotein activator 1F
  • Synonyms
    CBWD6, CBWD7
  • Links
    NCBI Gene ID: 644019
    neXtProt AC: NX_Q4V339
    UniProt: Q4V339

  • Chr Location
    9p11.2
Human Diseases
more
  • Diseases
    1 with Zng1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hydronephrosis, hydroureter, and double ureter, all CAKUT phentoypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    6
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024878 Ensembl Gene Model | MGI Sequence Detail 41695 C57BL/6J ±  kb
    transcript ENSMUST00000025815 Ensembl | MGI Sequence Detail 1929 Not Applicable  
    polypeptide ENSMUSP00000025815 Ensembl | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147682
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:325966 Weiss A, et al., Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Cell. 2022 Jun 9;185(12):2148-2163.e27
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory