Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccl11tm1Mer
Name:	C-C motif chemokine ligand 11; targeted mutation 1, Marc E Rothenberg
MGI ID:	MGI:2384435
Synonyms:	Eot-, eotaxin-, eotaxin-1
Gene:	Ccl11  Location: Chr11:81948658-81953781 bp, + strand  Genetic Position: Chr11, 49.84 cM
Alliance:	Ccl11tm1Mer page

Germline Transmission:	Earliest citation of germline transmission: J:38945
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All of exon 2 and the majority of exon 3 were replaced by a neomycin selection cassette. In addition to containing the 3' UTR, the deleted region encoded most of the mature protein. Transcript was undetected in homozygous mutant mice via Northern blot analysis of skin and lung RNA (the latter of which was isolated from mice treated with and subsequently challenged with OVA).

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ccl11 Mutation:	15 strains or lines available

Original:	J:38945 Rothenberg ME, et al., Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med. 1997 Feb 17;185(4):785-90
All:	29 reference(s)