Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Egr1tm1Jmi
Name:	early growth response 1; targeted mutation 1, Jeffrey Milbrandt
MGI ID:	MGI:2384433
Synonyms:	egr-1-, Egr1-, Egr-10, Egr-1ko, NGFI-A-
Gene:	Egr1  Location: Chr18:34994260-34998009 bp, + strand  Genetic Position: Chr18, 18.76 cM, cytoband C/D
Alliance:	Egr1tm1Jmi page

Germline Transmission:	Earliest citation of germline transmission: J:24948
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into a coding exon upstream of the DNA-binding domain via homologous recombination. The targeted mutation introduces several stop codons resulting protein truncation upstream of the DNA-binding domain. Gene expression and protein product were not observed in homozygous mutant ES cells. (J:24948)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

List all tumor models in MMHCdb carrying Egr1tm1Jmi

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egr1 Mutation:	19 strains or lines available

Original:	J:24948 Lee SL, et al., Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A. J Biol Chem. 1995 Apr 28;270(17):9971-7
All:	96 reference(s)