Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adipoqtm1Tka
Name:	adiponectin, C1Q and collagen domain containing; targeted mutation 1, Takashi Kadowaki
MGI ID:	MGI:2384094
Synonyms:	adipo-
Gene:	Adipoq  Location: Chr16:22965286-22976718 bp, + strand  Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
Alliance:	Adipoqtm1Tka page

Germline Transmission:	Earliest citation of germline transmission: J:77876
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in adipose tissues of homozygous mutant animals was confirmed by Northern blot analysis. Protein product was undetectable in serum of homozygous mutants. (J:77876)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adipoq Mutation:	40 strains or lines available

Original:	J:77876 Kubota N, et al., Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem. 2002 Jul 19;277(29):25863-6
All:	12 reference(s)