Hcktm1Hev
Targeted Allele Detail
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| Symbol: |
Hcktm1Hev |
| Name: |
hemopoietic cell kinase; targeted mutation 1, Harold E Varmus |
| MGI ID: |
MGI:2384049 |
| Synonyms: |
hck- |
| Gene: |
Hck Location: Chr2:152950388-152993361 bp, + strand Genetic Position: Chr2, 75.41 cM
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| Alliance: |
Hcktm1Hev page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:16994
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| Parent Cell Line: |
AB1 (ES Cell)
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| Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: This dicistronic locus was disrupted by the insertion of a neomycin selection cassette downstream of both start codons. Elongated transcript, containing the neo transgene, and a shortened transcript, resulting from the splicing of exons 1 and 3, were detected in homozygous mutant mice by Northern blot and RT-PCR analyses. Normal protein was undetected by Western blot analysis of bone marrow, and though the absence of truncated carboxy terminal peptide was not directly confirmed, assays of immunoprecipitates verified a lack of protein kinase activity.
(J:16994)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Hck Mutation: |
29 strains or lines available
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| Original: |
J:16994 Lowell CA, et al., Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15;8(4):387-98 |
| All: |
59 reference(s) |
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Analysis Tools
