Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	F11tm1Gjb
Name:	coagulation factor XI; targeted mutation 1, George J Broze
MGI ID:	MGI:2384015
Synonyms:	FXI-
Gene:	F11  Location: Chr8:45694211-45715068 bp, - strand  Genetic Position: Chr8, 25.14 cM
Alliance:	F11tm1Gjb page

Germline Transmission:	Earliest citation of germline transmission: J:40270
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 5, encoding a portion of the second apple domain, was disrupted by the insertion of a neomycin selection cassette. Sequence analysis showed that a frameshift mutation would be generated if exon 4 were to splice to exon 6 due to the excision of the disrupted exon 5. Transcript was undetected in homozygous mutant mice via Northern blot and RT-PCR analyses of total hepatic RNA. (J:40270)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any F11 Mutation:	53 strains or lines available

Original:	J:40270 Gailani D, et al., A murine model of factor XI deficiency. Blood Coagul Fibrinolysis. 1997 Mar;8(2):134-44
All:	22 reference(s)