Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Sh2b3tm1Paw Name: SH2B adaptor protein 3; targeted mutation 1, Tony Pawson MGI ID: MGI:2383957 Synonyms: Lnk- Gene: Sh2b3  Location: Chr5:121953551-121975709 bp, - strand  Genetic Position: Chr5, 61.99 cM Alliance: Sh2b3tm1Paw page

Primary splenomegaly and extramedullary hematopoiesis in Sh2b3tm1Paw/Sh2b3tm1Paw mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:77248
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 1.6 Kb of sequence, encompassing exons 2 through 7, was replaced with a neomycin selection cassette. The absence of transcript and protein was determined in homozygous mutant mice by Northern and Western blot analyses. (J:77248)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sh2b3 Mutation:	22 strains or lines available

Original:	J:77248 Velazquez L, et al., Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med. 2002 Jun 17;195(12):1599-611
All:	15 reference(s)