Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Klf4tm1Efu
Name:	Kruppel-like transcription factor 4 (gut); targeted mutation 1, Elaine Fuchs
MGI ID:	MGI:2183936
Synonyms:	Klf4-
Gene:	Klf4  Location: Chr4:55527143-55532466 bp, - strand  Genetic Position: Chr4, 29.76 cM
Alliance:	Klf4tm1Efu page

Germline Transmission:	Earliest citation of germline transmission: J:56495
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 2.8 kb region of the gene encompassing part of exon 1, exon 2, and exon 3 was replaced with a PGK-neo cassette via homologous recombination. The targeted region encodes the translation initiation codon and the first of 3 zinc finger domains. Northern blot analysis and immunohistochemistry of skin sections from homozygous mutant animals verified the absence of gene expression. (J:56495)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf4 Mutation:	24 strains or lines available

Original:	J:56495 Segre JA, et al., Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet. 1999 Aug;22(4):356-60
All:	10 reference(s)