Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mapk3tm1Gpg
Name:	mitogen-activated protein kinase 3; targeted mutation 1, Gilles Pages
MGI ID:	MGI:2183906
Synonyms:	ERK1-, MAPK-, p44 MAPK-
Gene:	Mapk3  Location: Chr7:126358798-126364988 bp, + strand  Genetic Position: Chr7, 69.25 cM
Alliance:	Mapk3tm1Gpg page

Germline Transmission:	Earliest citation of germline transmission: J:58468
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassette deleted exonic sequence encoding the essential kinase subdomains 5 and 6. Immunoblot analysis of protein extracts from MEFs and various tissues showed an absence of protein in homozygous mutant mice. (J:58468)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	24 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk3 Mutation:	26 strains or lines available

Original:	J:58468 Pages G, et al., Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science. 1999 Nov 12;286(5443):1374-7
All:	69 reference(s)