Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ncoa2tm1.2Ipc
Name:	nuclear receptor coactivator 2; targeted mutation 1.2, I Pierre Chambon
MGI ID:	MGI:2183803
Synonyms:	SRC-2-, TIF-2-, TIF2-, TIF2L-
Gene:	Ncoa2  Location: Chr1:13209329-13444307 bp, - strand  Genetic Position: Chr1, 4.12 cM, cytoband A3-A5
Alliance:	Ncoa2tm1.2Ipc page

Germline Transmission:	Earliest citation of germline transmission: J:78075
Parent Cell Line:	H1 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was generated by breeding mice carrying Ncoa2tm1Ipc with transgenic mice expressing cre recombinase via the CMV promoter. The expression of cre resulted in the excision of the floxed region containing the neo transgene and the exon encoding the nuclear receptor interaction domain. Sequence analysis showed that a frameshift mutation begining at codon 375 introduced a stop codon at position 490. Immunohistochemical staining of homozygous mutant testes showed an absence of reactivity. (J:78075)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa2 Mutation:	76 strains or lines available

Original:	J:78075 Gehin M, et al., The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol. 2002 Aug;22(16):5923-37
All:	24 reference(s)