Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ctbp1tm1Sor
Name:	C-terminal binding protein 1; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:2183644
Synonyms:	Ctbp1-
Gene:	Ctbp1  Location: Chr5:33405067-33432338 bp, - strand  Genetic Position: Chr5, 17.52 cM, cytoband B1
Alliance:	Ctbp1tm1Sor page

Germline Transmission:	Earliest citation of germline transmission: J:77905
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon encoding amino acids 55 through 102 was replaced with a floxed neomycin selection cassette. RT-PCR and sequence analyses showed that the disrupted exon was excised and the resultant splicing of the adjacent exons introduced a frameshift mutation. The absence of protein was verifed by Western blot analysis of lysates obtained from homozygous mutant embyros. (J:77905)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctbp1 Mutation:	35 strains or lines available

Original:	J:77905 Hildebrand JD, et al., Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol. 2002 Aug;22(15):5296-307
All:	5 reference(s)