Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Icmttm1Hzo
Name:	isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Huda Y Zoghbi
MGI ID:	MGI:2183607
Synonyms:	pccmt-
Gene:	Icmt  Location: Chr4:152381684-152391578 bp, + strand  Genetic Position: Chr4, 83.02 cM
Alliance:	Icmttm1Hzo page

Germline Transmission:	Earliest citation of germline transmission: J:77742
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A floxed region containing exons 2 through 4 was excised via the in vitro expression of cre recombinase. The deleted sequence encoded amino acids 65 through 224. Northern blot analysis of heterozygous mice showed an approximately 50% reduction in transcript levels, whereas transcript was undetected in homozygous mutant embryos by RT-PCR analysis. (J:77742)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icmt Mutation:	11 strains or lines available

Original:	J:77742 Lin X, et al., Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice. Gastroenterology. 2002 Jul;123(1):345-51
All:	1 reference(s)