Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pth1rtm3Hmk
Name:	parathyroid hormone 1 receptor; targeted mutation 3, Henry M Kronenberg
MGI ID:	MGI:2183514
Synonyms:	Pthrd/d
Gene:	Pth1r  Location: Chr9:110551153-110576213 bp, - strand  Genetic Position: Chr9, 60.56 cM, cytoband F
Alliance:	Pth1rtm3Hmk page

Germline Transmission:	Earliest citation of germline transmission: J:77683
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: This hypomorphic allele was identified in conjunction with Pthrtm2Hmk. Southern blot analyses showed three copies of the targeting vector, containing a floxed exon 1, at the endogenous locus. Levels of transcript were determined to be reduced in homozygous mutant mice via in situ hybridization of the growth plate and Northern blot analysis of total renal RNA. (J:77683)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pth1r Mutation:	28 strains or lines available

Original:	J:77683 Kobayashi T, et al., PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development. 2002 Jun;129(12):2977-86
All:	2 reference(s)