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Dlgap5 Gene Detail
Summary
  • Symbol
    Dlgap5
  • Name
    DLG associated protein 5
  • Synonyms
    C86398, Dlg7, Hurp, mKIAA0008
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183453
    NCBI Gene: 218977
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:47625236-47655864 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 24.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183453
 protein coding gene Chr14:47625236-47655864 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021222
 protein coding gene Chr14:41135241-41170623 (-)
A/J MGP_AJ_G0021170
 protein coding gene Chr14:39892187-39922943 (-)
AKR/J MGP_AKRJ_G0021148
 protein coding gene Chr14:41444378-41477922 (-)
BALB/cJ MGP_BALBcJ_G0021173
 protein coding gene Chr14:39951189-39981714 (-)
C3H/HeJ MGP_C3HHeJ_G0020957
 protein coding gene Chr14:41230122-41263866 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021608
 protein coding gene Chr14:42875669-42907031 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019167
 protein coding gene Chr14:39246554-39278560 (-)
CAST/EiJ MGP_CASTEiJ_G0020482
 protein coding gene Chr14:38348875-38381499 (-)
CBA/J MGP_CBAJ_G0020923
 protein coding gene Chr14:44251031-44290284 (-)
DBA/2J MGP_DBA2J_G0021046
 protein coding gene Chr14:39782536-39813029 (-)
FVB/NJ MGP_FVBNJ_G0021031
 protein coding gene Chr14:39526103-39557039 (-)
LP/J MGP_LPJ_G0021116
 protein coding gene Chr14:41411284-41443842 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021056
 protein coding gene Chr14:43605852-43639643 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021641
 protein coding gene Chr14:40985062-41015460 (-)
PWK/PhJ MGP_PWKPhJ_G0020231
 protein coding gene Chr14:36661336-36694401 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020055
 protein coding gene Chr14:37109123-37140146 (-)
WSB/EiJ MGP_WSBEiJ_G0020538
 protein coding gene Chr14:41084142-41117549 (-)



Homology
more
  • Human Ortholog
    DLGAP5, DLG associated protein 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLGAP5, DLG associated protein 5
  • Synonyms
    DLG7, HURP
  • Links
    NCBI Gene ID: 9787
    neXtProt AC: NX_Q15398
    UniProt: Q15398

  • Chr Location
    14q22.3; chr14:55148112-55191608 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display female infertility resulting from a defect in decidualization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    25
  • cDNA Data
    100
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 218977 NCBI Gene Model | MGI Sequence Detail 30629 C57BL/6J ±  kb
    transcript NM_144553 RefSeq | MGI Sequence Detail 2755 C57BL/6  
    polypeptide Q8K4R9 UniProt | EBI | MGI Sequence Detail 808 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 100
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1353581, MGI:2145876
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:167991 Breuer M, et al., HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells. J Cell Biol. 2010 Dec 27;191(7):1251-60
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory