Pkd1tm1Shh
Targeted Allele Detail
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Symbol: |
Pkd1tm1Shh |
Name: |
polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie |
MGI ID: |
MGI:2183431 |
Synonyms: |
Pkd1-, Pkd1del2, Pkd1del2-6 |
Gene: |
Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
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Alliance: |
Pkd1tm1Shh page
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Pkd1tm1.1Pcha/Pkd1tm1Shh mice show early-onset and rapidly progressive cystic disease
Show the 8 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:77927
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of exons 2-5 and part of exon 6 with a neomycin resistance cassette via homologous recombination. The gene targeting even results in a frameshift. Absence of gene expression in E12.5 embyros was confirmed by Western blot analysis.
(J:77927)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pkd1 Mutation: |
153 strains or lines available
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Original: |
J:77927 Muto S, et al., Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Hum Mol Genet. 2002 Jul 15;11(15):1731-42 |
All: |
10 reference(s) |
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