Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnj6tm1Stf
Name:	potassium inwardly-rectifying channel, subfamily J, member 6; targeted mutation 1, Markus Stoffel
MGI ID:	MGI:2183429
Synonyms:	GIRK2-
Gene:	Kcnj6  Location: Chr16:94549495-94798560 bp, - strand  Genetic Position: Chr16, 55.44 cM
Alliance:	Kcnj6tm1Stf page

Germline Transmission:	Earliest citation of germline transmission: J:38206
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 2. While normal transcript was absent, truncated message was detected in homozygous mutant mice via RT-PCR analysis. Neither normal protein nor protein encoded by the truncated transcript was detected by Western blot analysis, using antibodies directed against the amino and carboxy termini. (J:38206)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnj6 Mutation:	26 strains or lines available

Original:	J:38206 Signorini S, et al., Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):923-7
All:	42 reference(s)