Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pfn1tm1Wit
Name:	profilin 1; targeted mutation 1, Walter Witke
MGI ID:	MGI:2183296
Synonyms:	pfn1ko
Gene:	Pfn1  Location: Chr11:70542676-70545470 bp, - strand  Genetic Position: Chr11, 43.21 cM, cytoband A-D
Alliance:	Pfn1tm1Wit page

Germline Transmission:	Earliest citation of germline transmission: J:77643
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Disruption of the locus was achieved by the insertion of a neomycin selection cassette at the start codon. Western blot analysis of thymocyte lysates showed a reduction in protein levels of approximately 50% in heterozygous mutant mice. (J:77643)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pfn1 Mutation:	10 strains or lines available

Original:	J:77643 Witke W, et al., Profilin I is essential for cell survival and cell division in early mouse development. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3832-6
All:	4 reference(s)